Joseph Kosuth. 1965.
"Box, Cube, Empty, Clear, Glass - A Description."
Glass cubes with black lettering
My research interests consist of several theoretical, statistical,
and analytical topics within the broad area of molecular evolution.
Elucidation of the relative roles of mutation and drift versus
purifying selection in determining the pattern of nucleotide
substitution. A major part of this study involves studies of
the methodology of inferring selection from comparative genomic data.
Producing dynamic and static descriptions of the compositional
features of genomes. Studying compositionally homogeneous regions
Assessment of the efficiency and efficacy limits of alignment
and phylogenetic reconstruction methods.
Assessing of the relative contributions of different molecular
mechanisms in generating gaps (deletions and insertions) in DNA
evolution. Such studies are useful in determining empirical gap-penalty
values for usage in computer alignment algorithms.
Correcting errors in multiple sequence alignments.
Identification of pseudogenes within completely sequenced genomes
and determination of nonfunctionalization times.
Assessing mutation rate variation within and between genomes.
Physico-chemical characterization of deleterious and neutral
Evolution of multiprotein-coding genes and reconstruction of
the order of internal gene duplications.
Determination of the validity and applicability of the
"molecular clock" concept to protein-coding genes and pseudogenes
at the inter- and intraordinal levels.
Reconstruction of phylogenetic relationships among and within
eutherian orders. Such studies are also concerned with questions
pertaining to the monophyly or paraphyly of higher taxa.
Frantisek Kupka. c. 1907.
"The Yellow Scale." Oil on canvas