New publication: p53 confers germline tolerance of P-element activity.

Check out Sadia Tasnim’s new paper in Developmental Biology, describing how DNA damage response pathways respond to P-element transposition. Through a combination of classical genetics and confocal microscopy, Sadia confirmed the long suspected role of the DNA damage response in driving germline loss in response to P-element activity. She also demonstrated a key role for the tumor suppressor p53 in conferring germline tolerance of P-element transposition. Congratulations Sadia!

Tasnim, S., and Kelleher E.S. (2017). p53 is required for female germline stem cell maintenance in P- element hybrid dysgenesis. Dev. Biol. 

New publication: Targeted resequencing of P-elements 2

Check Shuo Zhang’s new paper in Mobile DNA, in which he describes a targeted resequencing method to enrich for polymorphic insertions of active TE families. He also proposes a new approach for estimating the frequency of polymorphic TE insertions from whole genome resequencing data. Great work Shuo!

Zhang, S., and E. S. Kelleher, 2017 Targeted identification of TE insertions in a Drosophila genome through hem-specific PCR. Mobile DNA 8(1).

STEGG Symposium

Several Kelleher lab members were delighted to attend the Southeast Texas Evolutionary Genetics and Genomic Symposium on June 2nd, hosted this year by our colleagues at Texas A&M Galveston. Congratulations to Jyoti Lama for taking second prize in the poster session for her work on the relationship between responder satellite and P-elememt hybrid dysgenesis. Congratulations to Shuo Zhang for giving a great talk on the evolution of P-element repression in natural populations of D. melanogaster

New publication: P and hobo elements in hybrid dysgenesis

Check out the honor’s thesis of lab alumnus Satyam Srivastav on the role of P-elements and hobo elements in inducing hybrid dysgenesis, which was recently published in G3. Satyam’s work suggested that P-element dosage explains little of the existing genetic variation in paternal induction of hybrid dysgenesis in natural population of D. melanogaster.

Srivastav, S. P., and E. S. Kelleher, 2017 Paternal Induction of Hybrid Dysgenesis in Drosophila melanogaster Is Weakly Correlated with Both P-Element and hobo Element Dosage. G3 (Bethesda). 7: 1487–1497.

Congratulations Recent Graduates!

Congratulations to Uche Akoma and Jaweria Jaweria on their recent graduation. Both students received a B.S. in Biology on May 13th, 2017.

Congratulations Sadia!

Sadia Tasnim was awarded a Summer Undergraduate Research Fellowship to pursue an independent research project this summer. Sadia plans to examine the role of DNA damage signalling and cell cycle regulation in P-element hybrid dysgenesis. Way to go, Sadia!


The Kelleher Lab has received an NSF grant to examine the host-TE evolutionary dynamics in Drosophila melanogaster! Our four-year project will combine genome-wide association, experimental evolution, and population genomics to examine the historical invasion of the Drosophila melanogaster genome by the P-element DNA transposon, and characterize the evolution of host repression. You can read more about our project on the NSF website.

Welcome New Lab Members!

We are pleased to welcome new colleagues to the lab for the spring semester. Uche Akoma, Vivan Chen, Donald Hubbard, Lily Ortega, and Sadia Tasnim will be examining natural variation in P-element repression as undergraduate researchers. Shuo Zhang is a rotating graduate student who is interested in piRNA mediated TE regulation. Chris Gonzales is our new shared lab manager with the Meisel Lab. Maryam Hilmi is a new undergraduate assisting Chris in the molecular biology lab. Welcome all!

Hello Houston!

The Kelleher Lab is live online and getting settled in its home at UH!

© Erin Kelleher 2013