Our research interests lie in the structural and functional basis of receptor–ligand interactions, which are relevant to human health and disease. Much of our studies aim to elucidate the molecular recognition properties governing receptor interactions with a ligand, and subsequent molecular events that couple ligand recognition to receptor activation. Many of the systems we study are related to the interactions between the host cell and environmental cues.
Structural studies are then complemented by functional approaches using molecular biology and protein engineering to dissect structural information, design proteins or peptides with modified specificities and activities, and ultimately contribute to the development of biologics with therapeutic potential.
The Şen Lab is a multidisciplinary group that encompasses people from
various talents and backgrounds.
The study of life through the lenses of macromolecules.
Metabolic and chemical processes within living organisms.
Physical phenomena in life, and the mathematics that explain them.