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University of Houston Center for Molecular Biophysics
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Glen B. Legge
Assistant Professor
Ph.D. University of Cambridge
Office: HSC 406
Phone: (713) 743-8380
email: glegge@uh.edu
In 2001 I joined the Division of Biochemistry at the University of Houston
(UH), as an Assistant Professor in the Division of Biochemistry.
This appointment followed a period at The
Scripps Research Institute in La Jolla, California, where I completed my
post-doctoral training.I attained my
PhD in 1996 from Cambridge University in the UK, and graduated from the
University of Western Australia in 1993.
My research vision is to use
structural biology to link the fields of biology and chemistry by an
understanding of the molecular mechanisms of biological processes.
Selected Publications
1. Ampapathi R., Lou I., Creath A.L., Blanke S.,
Legge G.B. (2007)
Order - disorder - order transitions mediate the activation of Cholera Toxin
J. Mol. Biol.. (Submitted with revisions)
2. Sen M.,
Legge G.B. (2007)
Pactolus I-domain: Functional Switching of the Rossman Fold
Proteins. 68(3): 626-635
3. Craft, Jr. J.,
Legge G.B. (2005)
An AMBER/DYANA/MOLMOL Phosphorylated Amino Acid Library Set and Incorporation
into NMR Structure Calculations
J. Biomol. NMR. 33(1): 15-24
4. Xia Y.,
Legge G.B., Jun K., Lee H., and Gao X.(2005)
IP-COSY, Totally In-Phase 2D Correlation Spectroscopy
Mag. Reson. in Chem.. 43:372-379
5. Shao H., Xu X., Mastrangelo M.A., Sha W., Jing N., Cook R.G., Legge G.B. and Tweardy D.J. (2004)
Structural requirements for STAT3 binding to phosphotyrosine
ligands containing the YXXQ motif J. Biol. Chem. 279(18):18967-73
6. Legge G.B., Martinez-Yamout M., Hamberly D. Trinh T. Lee B.M., Dyson H.J., Wright P.E.
(2004) ZZ-domain of CBP - an unusual Zinc Finger Fold in a Protein Interaction Module
J. Mol. Biol.
343:1081-1093
7. Legge G.B., Morris G.M., Sanner M.F., Takada
Y., Olson A.J. and Grynszpan F. (2002) A model for the aL
I-domain / ICAM-1 D1 interaction suggests subtle changes in loop orientation
determine ligand specificity
Proteins
48:151-160
8. Duggan B.M., Legge G.B., Dyson H.J. and Wright P.E. (2001)
SANE (Structure Assisted NOE Evaluation): An automated model-based approach for NOE assignment
using chemical shift, distance and NOE contribution filtering J. Biomol. NMR 19(4): 321-329.
9. Legge G.B., Kriwacki R.W., Chung J., Hommel U.,
Ramage P., Dyson.H.J. and Wright P.E. (2000) NMR solution structure of the
I-domain of human leukocyte function associated Antigen-1. J. Mol. Biol.
295(5): 1251-1264.
10. Kallen J., Wezenbach
K., Ramage P., Kriwacki R., Legge G., Cottens S., Weitz-Schmidt G. and Hommel U. (1999) Structural Basis for LFA-1 inhibition upon
lovastatin binding to the CD11a I-domain. J. Mol. Biol. 292(1): 1-9.
11. Poget S.F., Legge G.B., Proctor M.P., Butler
J.G., Bycroft M. and Williams R.L. (1999) The
Structure of a tunicate C-type lectin from Polyandrocarpa misakiensis
complexed with D-galactose. J. Mol. Biol. 290:
867-879.
Contact Details
Email: glegge@uh.edu
Tel: (713) 743 8380
Fax: (713) 743 2636
University of Houston
Department of Biology and Biochemistry
406 HSC
Houston, Texas 77204-5001
USA
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