University of Houston Center for Molecular Biophysics

Glen B. Legge
Assistant Professor Ph.D. University of Cambridge
Office: HSC 406
Phone: (713) 743-8380

In 2001 I joined the Division of Biochemistry at the University of Houston (UH), as an Assistant Professor in the Division of Biochemistry. This appointment followed a period at The Scripps Research Institute in La Jolla, California, where I completed my post-doctoral training.I attained my PhD in 1996 from Cambridge University in the UK, and graduated from the University of Western Australia in 1993.

My research vision is to use structural biology to link the fields of biology and chemistry by an understanding of the molecular mechanisms of biological processes. 

Selected Publications

1. Ampapathi R., Lou I., Creath A.L., Blanke S., Legge G.B. (2007) Order - disorder - order transitions mediate the activation of Cholera Toxin J. Mol. Biol.. (Submitted with revisions)

2. Sen M., Legge G.B. (2007) Pactolus I-domain: Functional Switching of the Rossman Fold
Proteins. 68(3): 626-635

3. Craft, Jr. J., Legge G.B. (2005) An AMBER/DYANA/MOLMOL Phosphorylated Amino Acid Library Set and Incorporation into NMR Structure Calculations J. Biomol. NMR. 33(1): 15-24

4. Xia Y., Legge G.B., Jun K., Lee H., and Gao X.(2005) IP-COSY, Totally In-Phase 2D Correlation Spectroscopy Mag. Reson. in Chem.. 43:372-379

5. Shao H., Xu X., Mastrangelo M.A., Sha W., Jing N., Cook R.G., Legge G.B. and Tweardy D.J. (2004) Structural requirements for STAT3 binding to phosphotyrosine ligands containing the YXXQ motif J. Biol. Chem. 279(18):18967-73

6. Legge G.B., Martinez-Yamout M., Hamberly D. Trinh T. Lee B.M., Dyson H.J., Wright P.E. (2004) ZZ-domain of CBP - an unusual Zinc Finger Fold in a Protein Interaction Module J. Mol. Biol. 343:1081-1093

7. Legge G.B., Morris G.M., Sanner M.F., Takada Y., Olson A.J. and Grynszpan F. (2002) A model for the aL I-domain / ICAM-1 D1 interaction suggests subtle changes in loop orientation determine ligand specificity Proteins 48:151-160

8. Duggan B.M., Legge G.B., Dyson H.J. and Wright P.E. (2001) SANE (Structure Assisted NOE Evaluation): An automated model-based approach for NOE assignment using chemical shift, distance and NOE contribution filtering J. Biomol. NMR 19(4): 321-329.

9. Legge G.B., Kriwacki R.W., Chung J., Hommel U., Ramage P., Dyson.H.J. and Wright P.E. (2000) NMR solution structure of the I-domain of human leukocyte function associated Antigen-1. J. Mol. Biol. 295(5): 1251-1264.

10. Kallen J., Wezenbach K., Ramage P., Kriwacki R., Legge G., Cottens S., Weitz-Schmidt G. and Hommel U. (1999) Structural Basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain. J. Mol. Biol. 292(1): 1-9.

11. Poget S.F., Legge G.B., Proctor M.P., Butler J.G., Bycroft M. and Williams R.L. (1999) The Structure of a tunicate C-type lectin from Polyandrocarpa misakiensis complexed with D-galactose. J. Mol. Biol. 290: 867-879.

Contact Details

Email:                    Tel: (713) 743 8380                      Fax: (713) 743 2636

University of Houston
Department of Biology and Biochemistry
406 HSC
Houston, Texas 77204-5001