Class Meetings: Tuesday and Thursday, 1:00-3:00 PM, HSC402B
Reminder! Presentation Schedule
November 29 (Tuesday) - papers #2, 4, 8
December 1 (Thursday) - papers #1, 6, 9
Lecture Notes
Lecture 7 - Lecture 8Lecture 9 - Lecture 10 (& Review for exams)
Project topics & papers
A. Protein Stability & Folding:
1. Peterson et al. PNAS (2010) 107(41):17739-44. Secretion of a bacterial virulence factor is driven by the folding of a C-terminal segment.
2. Das et al. PNAS (2011) 108(26):10514-9. Aggregation of gamma-crystallins associated with human cataracts via domain swapping at the C-terminal beta-strands.
3. Price et al. PNAS (2011) 108(34):14127-32. Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts.
B. Structural Bases of Biological Functions:
4. Lazarus et al. Nature (2011) 469(7331):564-7. Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
5. Lizak et al. Nature (2011) 474(7351):350-5. X-ray structure of a bacterial oligosaccharyltransferase.
6. Nash et al. PNAS (2011) 108(23):9449-54. Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein.
7. Román-Hernández et al. Mol Cell (2011) 43(2):217-28. The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease.
C. Bacterial Pathogenesis:
8. Kang et al. PNAS (2009) 106(40):16967-71. The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds.
9. Zoll et al. PLoS Pathog. (2010) 6(3):e1000807. Structural basis of cell wall cleavage by a staphylococcal autolysin.
10. Yoon et al. Nat Struct Mol Biol (2011) 18(9):1028-35. An unusual dimeric structure and assembly for TLR4 regulator RP105-MD-1.