Publications

  1. Ruckthong, L.; Zastrow, M. L.; Stuckey, J. A.; Pecoraro, V. L. A Crystallographic Examination of Predisposition Versus Preorganization in de Novo Designed Metalloproteins. J. Am. Chem. Soc. 2016, 138, 11979-11988.

  2. Zastrow, M. L.*; Radford, R. J.*; Chyan, W.; Anderson, C. T.; Zhang, D. Y.; Loas, A.; Tzounopoulos, T.; Lippard, S. J. Reaction-Based Probes for Imaging Mobile Zinc in Live Cells and Tissues. ACS Sens. 2016, 1, 32-39. *Co-first authors.

  3. Anderson, C. T.; Radford, R. J.; Zastrow, M. L.; Zhang, D. Y.; Apfel, U.-P.; Lippard, S. J.; Tzounopoulos, T. Modulation of extrasynaptic NMDA receptors by synaptic and tonic zinc. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, E2705-E2714.

  4. Rivera-Fuentes, P.; Wrobel, A.; Zastrow, M. L.; Khan, M.; Georgiou, J.; Luyben, T. T.; Roder, J. C.; Okamoto, K.; Lippard, S. J. A far-red emitting probe for unambiguous detection of mobile zinc in acidic vesicles and deep tissue. Chem. Sci. 2015, 6, 1944-1948.

  5. Yu, F.; Cangelosi, V. M.; Zastrow, M. L.; Tegoni, M.; Plegaria, J. S.; Tebo, A. G.; Mocny, C. S.; Ruckthong, L.; Qayyum, H.; Pecoraro, V. L. Protein design: toward functional metalloenzymes. Chem. Rev. 2014, 114, 3495-3578.

  6. Zastrow, M. L. & Pecoraro, V. L. Designing hydrolytic zinc metalloenzymes. Biochemistry 2014, 53, 957-978.

  7. Zastrow, M. L. & Pecoraro, V. L. Designing functional metalloproteins: from structural to catalytic metal sites. Coord. Chem. Rev. 2013, 257, 2565-2588

  8. Zastrow, M. L. & Pecoraro, V. L. Influence of Active Site Location on Catalytic Activity in de Novo-Designed Zinc Metalloenzymes. J. Am. Chem. Soc. 2013, 135, 5895-5903

  9. Zastrow, M. L.; Peacock, A. F. A.; Stuckey, J. A.; Pecoraro, V. L. Hydrolytic catalysis and structural stabilization in a designed metalloprotein. Nature Chem. 2012, 4, 118-123