The Zastrow group uses biological and
chemical approaches to uncover and examine the roles of
essential metals in the gut microbiota. Our research techniques
span a range of areas centered around bioinorganic chemistry and
chemical biology, including protein biochemistry and protein
design, molecular biology, synthesis, cell imaging, and
absorption and fluorescence spectroscopy.
Projects in the group focus on: 1)
elucidating essential metal utilization in gut bacteria, 2)
imaging metal ion dynamics in gut bacteria, and 3) modulating
bacterial cell-to-cell communication. We are interested in
understanding how metals in gut microbes affect host health,
disease, and immune response and hope to foster the development
of novel therapeutics.