Peer-reviewed publications (in chronological order)

  1. Salem G.J., R.F. Zernicke, A.C. Vailas and D.A. Martinez. Biomechanical and biochemical Changes in lumbar vertebrae of rapidly growing rats. Amer. J. Physiol. 256: R259-R263, 1989.
  2. Zernicke, R.F., A.C. Vailas, G.J. Salem and D.A. Martinez. Spaceflight effects on biomechanical and biochemical changes in lumbar vertebrae of rapidly growing rats. Amer. J. Physiol. 258:R1327-R1332, 1990.
  3. Vailas, A.C., R.F. Zernicke, R.E. Grindeland, A. Kaplansky, G.N. Durnova, K-C Li and D.A. Martinez. Spaceflight effects on rat cortical bone geometry, biomechanics, and biochemistry. FASEB J. 4: 47-54, 1990.
  4. Orth, M.W., D.A. Martinez, M.E. Cook, and A.C. Vailas. Nonreducible cross-link formation in tibial dischondroplastic growth plate cartilage from broiler chickens fed homocysteine. Biochem. Biophys. Res. Comm. 179: 1582-1586, 1991.
  5. Martinez, D.A., A.C. Vailas and R.E. Grindeland. Cortical bone maturation in young hypophysectomized rats. Am. J. Physiol. 260 (Endocrinol. Metab. 23): E690-E694, 1991.
  6. Vailas, A.C., R. Vanderby Jr., D.A. Martinez, R.B. Ashman, M.J. Ulm, R.E. Grindeland, G.N. Durnova, and A. Kaplansky. Adaptations of young adult rat cortical bone to 14 days of spaceflight. J. Appl. Physiol. 73 (2), Suppl.: 4S-9S, 1992.
  7. Gosselin, L.E., D.A. Martinez, A.C. Vailas, and G.C. Sieck. Interstitial space and collagen alterations of the developing rat diaphragm. J. Appl. Physiol. 74: 2450-2455, 1993.
  8. Salem, G.J., R.F. Zernicke, D.A. Martinez and A.C. Vailas. Adaptations of immature trabecular bone to moderate exercise: Geometrical, biochemical, and biomechanical correlates. Bone 14: 647-654, 1993.
  9. Orth, M.W., D.A. Martinez, M.E. Cook, and A.C. Vailas. The presence of lysylpyridinoline in the hypertrophic cartilage of newly hatched chicks. Biochem. Biophys. Acta 1157: 229-232, 1993.
  10. Gosselin, L.E., D.A. Martinez, A.C. Vailas, and G.C. Sieck. Passive length-force properties of the senescent diaphragm: relationship to collagen characteristics. J. Appl. Physiol. 76: 2680-2685, 1994.
  11. Hurschler, C., R. Vanderby Jr., D.A. Martinez, A.C. Vailas, and W.D. Turnipseed. Mechanical and biochemical analyses of tibial compartment fascia in chronic compartment syndrome. Ann. Biomed. Eng. 22: 272-279, 1994.
  12. Martinez, D.A., M.J. Zuscick, M. Ishibe, R.N. Rosier, P.R. Romano, J.E. Cushing, and J. E. Puzas. Identification of functional insulin-like growth factor-II/mannose-6-phosphate receptors in isolated bone cells. J. Cell. Biochem. 59(2): 246-257, 1995.
  13. Gosselin, L.E., G.C. Sieck, R.A. Aleff, D.A. Martinez and A.C. Vailas. Changes in diaphragm muscle collagen metabolism following acute unilateral denervation. J. Appl. Physiol. 79: 1249-1254, 1995.
  14. Martinez, D.A., M.W. Orth, K.E. Carr, R. Vanderby Jr. and A.C. Vailas. Cortical bone growth and maturational changes in the dwarf rat induced by human growth hormone. Amer. J. Physiol. 270 (Endocrinol. Metab. 33) E51-E59, 1996.
  15. Kohles, S.S., D.A. Martinez, J.R. Bowers, A.C. Vailas and R. Vanderby Jr. Effect of a growth hormone treatment on bone orthotropic elasticity in dwarf rats. Ann. Biomed. Eng. 25(1): 77-85, 1997.
  16. Martinez, D.A., M.W. Orth, K.E. Carr, R. Vanderby Jr., M. Vasques, R.E. Grindeland and A.C. Vailas. Cortical bone responses to acute 2G hypergravity in growing rats. Aviat. Space Environ. Med. 69: (6) A17-A22, 1998.
  17. Kohles, S.S. and D.A. Martinez. Elastic and physiochemical relationships within cortical bone. J. Biomed. Mater. Res. 49: 479-488, 2000.
  18. Martinez, D.A., P.E. Buckendahl, R.E. Grindeland, M.A. Dotsenko, A.J. Bigbee, and A.C. Vailas. Evaluation of bone and collagen metabolism by assessing urinary biomarkers in non-human primates. J. Gravit. Physiol. 7(1):S169-S170, 2000.
  19. Kyparos, A., M.W. Orth, A.C. Vailas and D.A. Martinez. Growth and maturational changes in dense fibrous connective tissue following 14 days of rhGH supplementation in the dwarf rat. Growth Horm IGF Res 12: 367-373, 2002.
  20. Martinez, D.A., D.J. Guhl, W.C. Stanley, and A.C. Vailas. Extracellular matrix maturation stable in the left ventricle of the normal and diabetic swine. Diabetes Res and Clin Pract 59 (1) 1-9, 2003.
  21. Sheu, T-J., E.M. Schwarz, D.A. Martinez, R.J. O’Keefe, R.N. Rosier, M.J. Zuscik and J.E. Puzas. A phage display technique identifies a novel regulator of cell differentiation. J Biol Chem 278 (1) 438-443, 2003.
  22. Provenzano, P.P., D.A. Martinez, R.E. Grindeland, K.W. Dwyer, J. Turner, A.C. Vailas, and R. Vanderby Jr. Hindlimb unloading alters ligament healing. J Appl Physiol 94 (1): 314-324, 2003.
  23. Gosselin, L.E. and D.A. Martinez. Impact of short term tumor necrosis factor-α blockade on diaphragm from dystrophic (mdx) mice. Muscle Nerve 30 (2) :244-246, 2004.
  24. Gosselin, L.E., J. Williams, M. Deering, D. Brazeau, S. Koury, D.A. Martinez. Localization and early time course of TGF-ß1 mRNA expression in dystrophic muscle. Muscle Nerve 30 (5):645-653, 2004.
  25. Choy, V.E., A. Kyparos, T.C. Crenshaw, A.C. Vailas and D.A. Martinez. The biphasic response of porcine tendon to recombinant porcine growth hormone. Growth Horm IGF Res 15 (1) 39-46, 2005.
  26. Hilton, M.J., L. Gutierrez, D.A. Martinez and D. Wells. EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. Bone 36(3): 379-386, 2005.
  27. A Kyparos, D.L. Feeback, C.S. Layne, D.A. Martinez, and M.S.F. Clarke. Mechanical stimulation of the plantar foot surface attenuates soleus muscle atrophy induced by hindlimb unloading in rats. J Appl Physiol 99 (2): 739-746, 2005.
  28. Provenzano, P.P., A.L. Alejandro-Osorio, K.W. Grorud, D.A. Martinez, A.C. Vailas, R.E. Grindeland, and R. Vanderby Jr. Systemic administration of IGF-I enhances healing in collagenous extracellular matrices: evaluation of loaded and unloaded ligaments. BMC Physiology 7:2 doi:10.1186/1472-6793-7-2, 2007.
  29. Martinez, D.A., A.C. Vailas, R. Vanderby, Jr., and R.E. Grindeland. and. Temporal extracellular matrix adaptations in ligament during wound healing and hindlimb unloading. Am J Physiol Regul Integr Comp Physiol 293: R1552-R1560, 2007.
  30. Martinez, D.A., P.E. Patterson-Buckendahl, A.T. Lust, K.M. Rangel, T.M. Hoban-Higgins, C.A. Fuller, and A.C. Vailas. A non-invasive analysis of urinary musculoskeletal collagen metabolism markers from rhesus monkeys subject to chronic hypergravity. J Appl. Physiol. 105(4):1255-1261, 2008, Epub 2008 Jul 24. doi:10.1152/ japplphysiol.00573.2007
  31. Buckendahl, P.E., L.A. Pohorecky, L. Kubovcakova, O. Krizanova, R.B. Martin, D.A. Martinez, and R. Kvetnansky. Ethanol and stress activate catecholamine synthesis in the adrenal: effects on bone. Ann NY Acad Sci 1148: 542-551, 2008.
  32. Kwak, H-B, J-H, Kim, K. Joshi, A. Yeh, D.A. Martinez, and J.M. Lawler. Exercise training reduces fibrosis and matrix metalloproteinase dysregulation in the aging rat heart. FASEB J 25(3): 1106-1017, 2011. (Epub Dec. 8, 2010)
  33. Lawler, J.M., M. Kunst, K. Joshi, J. Hord, Y. Lee, and D.A. Martinez. Regulation of nNos dislocation from the sarcolemma and remodeling during short-term mechanical unloading is redox-dependent in the rat soleus muscle. Science (submitted, 2011).

Current Scientific Publications in Progress

  1. D.A. Martinez, A.C. Vailas, A. Lust, R. Vanderby, Jr., C.E. Wade and R.E. Grindeland. IGF-1 impact on medial collateral ligament gene expression and maturation during wound healing and hindlimb unloading Am J Physiol (Endocr Metab) (in preparation, 2011).
  2. Martinez, D.A., J.M. Swift, K.M. Reddoch, and S.A. Bloomfield. The expression of extracellular matrix and growth factor genes in the regulation of dense fibrous connective tissues: “The impact of an stimulated resistance training on rat tendon and ligament during hindlimb unloading. J Appl Physiol (in preparation, 2011).
  3. Lawler, J.M., H.B. Kwak, J.-H. Kim, and D.A. Martinez.  Biphasic nature of stress-response during reloading in the rat soleus. Med Sci Sports and Exerc. (in preparation, 2011).