Research Support
Ongoing Research Support
07-NASA-HRP-2-0037
Hogan (PI) 7/1/08 – 6/30/11
NASA-Human Human Research Program
“Contributors to Long-Term Recovery of Bone Strength following Exposure to Microgravity.”
The major goal of this project is to assess the efficacy of various bone reloading regimens on the biomechanical, biochemical and molecular properties of tibia and femurs from hindlimb unloaded adult rats.
Role: Co-Investigator
Total Award: $1,023,379.00
NSF: 0650822
Cheng (PI) 6/5/07-5/31/10
National Science Foundation
“Laser Engineered Multilayer Bioactive Coatings with Hydroxyapatite Nano-Powders.”
The goal of this project is to investigate a novel multiple-layer laser coating process to form a functional gradient of nanoscale hydroxyapatite (HAp)/Ti coatings on Ti6Al4V metal substrates. The biocompatibility of the HAp/Ti coatings and osteoblasts-like cells will be tested to determine bone cell viability and characteristics.
Role: Co-Investigator
Total Award: $300,000.00
NFL Charities
Martinez (PI) 01/01/09 – 06/30/10
“The Impact of IGF-1 Gene Therapy to Improve Knee Ligament Wound Repair.”
The goal of this research is to develop and characterize Insulin-like growth factor gene therapy for use in the wounded rat medial collateral ligament (MCL) model. Characterization of primary rat MCL fibroblasts in vitro, as well as their use in vivo is the main objective of the project.
Role: PI
Total Award: $118,693.00
Pending Research Support
Department of Defense
Lawler (PI) Submitted October 2008
FY08 DRMRP (Department of Defense Congressionally Directed Medical Research Programs #DOD W81XWH-08-DRMRP-ATTDA
Submitted for 5 years: $2,800,000.00
“Stress Response and Antioxidant Protection: Translational Rehabilitation Therapy Promoting Prevention and Recovery of Muscle Atrophy from Disuse by Elevating.”
The goal of this project is to study novel therapeutics that protect against skeletal muscle atrophy, weakness, and injury which are of great interest to the Deployment Related Medical Research Program and the Department of Defense. The proposed study directly addresses and impacts Deployment Research Gap 5h: “Novel rehabilitation techniques…to facilitate recovery and return to duty.”
Role: Co-Investigator
Completed Research Support
NASA-NSBRI
Martinez (PI) 9/4/07 - 9/3/08
“The expression of extracellular matrix & growth factor genes in the regulation of dense fibrous connective tissues: The impact of an exercise re-loading paradigm on rat tendon and ligament during hindlimb unloading.”
Total Award: $60,747.00
NASA-NAG9-1152
Martinez (PI) 11/9/99-11/8/04
"Healing Response of Injured Rodent Knee Ligaments to Hindlimb Unweighting and the Therapeutic Efficacy of Growth Hormone."
Total Award: $799,345.00.
AHA-National
9930148N Martinez (PI) 1/1/98-12/31/03
"Adaptive Cardiac Connective Tissue Remodeling Through Directed Delivery Into Cardiac Myo-fibroblast Cells."
Total Award: $260,000.00.
NASA-UH/ISSO
Martinez (PI) 6/1/01-5/31/04
Post-Doctoral Student Fellowships Funded (Antonios Kyparos, Ph.D.)
"Using Dynamic Foot Pressure as a Countermeasure to Muscle Atrophy."
Total Award: $120,000.00
NASA-NAG-2-1284
Vailas (PI) 2/1/99-7/1/00
"A Non-Invasive Analysis of Musculoskeletal Collagen Metabolism from Urine of Rhesus Monkeys During Long Term 2G Hypergravity Perturbation."
Total Award: $25,000.00
Role: Co-Investigator
NASA-NAG-2-1089
Vailas (PI) 7/1/96-2/28/99
"An Evaluation of Collagen Metabolism in Non Human Primates Associated with the BION Space Program-Markers of Urinary Collagen Turnover and Muscle Tissue Gene Expression and Collagen Types."
Total Award: $209,417.00
Role: Co-Investigator
NIH-NIAMS, 1-F32-AR008384-01
Martinez (PI) 8/01/95 – 11/30/96.
National Institute of Arthritis and Musculoskeletal and Skin Diseases. PHS Individual NRSA Post-Doctoral Research Grant.
“In vitro bone remodeling.”
University of Rochester School of Medicine and Dentistry, Department of Orthopaedics, Musculoskeletal Research Laboratory, Rochester, NY.
Total Award: $48,246.00
Role P.I. (Post-Doctoral Fellow mentored by J. Edward Puzas).
NIH-NIAMS, 3R01AR028420-08S1
Martinez (PI) 8/01/93 – 7/31/95.
National Institute of Arthritis and Musculoskeletal and Skin Diseases. PHS Individual NRSA Supplement Post-Doctoral Research Grant.
“Regulation of Osteoblast Activity.”
University of Rochester School of Medicine and Dentistry, Department of Orthopaedics, Musculoskeletal Research Laboratory, Rochester, NY.
Total Awarded: $92,781.00
Role P.I. (Post-Doctoral Fellow mentored by J. Edward Puzas).